Transfersomes are ultra-deformable lipid-based vesicles designed for transdermal drug delivery. These vesicles enhance drug penetration through the skin by adapting their shape to pass through narrow pores, making them more efficient than conventional liposomes. Researchers use transfersomes to improve drug bioavailability, reduce systemic side effects, and optimize therapeutic outcomes. Their flexibility and ability to encapsulate both hydrophilic and lipophilic drugs make them valuable in pharmaceutical and biomedical applications.